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Left ventricular function in acute inflammatory peri-myocardial diseases – new insights and long-term follow-up

Marina Leitman13, Vladimir Tyomkin13, Eli Peleg13, Laurian Copel23, Zvi Vered13* and FACC, FESC

Author Affiliations

1 Department of Cardiology, Assaf Harofeh Medical Center, Zerifin, 70300, Israel

2 Department of Radiology, Assaf Harofeh Medical Center, Zerifin, Israel

3 Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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Cardiovascular Ultrasound 2012, 10:42  doi:10.1186/1476-7120-10-42

Published: 5 November 2012



Until recently acute inflammatory peri-myocardial syndromes have been associated with global rather regional left ventricular (LV) dysfunction. Recent advances in cardiac imaging with echocardiographic techniques and magnetic resonance imaging (MRI) permit comprehensive evaluation of global and regional LV function. Our study was aimed to assess regional LV function in 100 patients with acute perimyocarditis, and correlate these findings with the clinical presentation.


We report on 100 patients with acute perimyocarditis admitted during 2008–2011, in whom LV function was assessed by semi-quantitative wall motion score analysis on conventional echo. Long-term mortality and recurrent hospitalization were also assessed.


Wall motion score in 100 patients with acute perimyocarditis demonstrated a significant predominance of regional wall motion abnormalities in the infero-postero-lateral LV wall. These data correspond well with speckle tracking results of a subgroup of these patients published earlier. Recent MRI data show frequent late enhancement of contrast in the infero-lateral region of the LV in patients with perimyocarditis. These observations were useful in re-classification of our patients into one of the following groups: pure or predominant pericarditis, and pure or predominant myocarditis. Over a mean period of 37 months, there was no mortality. Though recurrent hospitalizations were rather frequent, no significant differences were observed among groups.


Regional wall motion abnormalities in the infero-postero-lateral segments of the LV are frequent in patients with acute perimyocarditis. Detailed echocardiographic examination early in the course of the disease should become a major factor in the clinical differentiation among the various clinical presentations of acute inflammatory peri-myocardial syndromes. The long-term outcome of these patients appears to be benign, though recurrent hospitalizations are not infrequent.

Pericarditis; Myocarditis; Left ventricular function