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Miscellaneous. CBFV: cerebral blood flow velocity. DHCPB: deep hypothermic cardiopulmonary bypass. |
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| Author [reference] |
Journal (Year of Publication) |
Type of study and Number of patients |
Main findings |
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| Trivedi U [8] |
Annals of Thoracic Surgery (1997) |
Randomized trial on 60 adult patients receiving either α-stat or pH stat management based CPB |
A decrease of CBF (evaluated by Xenon-133 and CBFV) is shown during 28° bypass in patients subjected to α-stat management. This is associated with a significant reduction in PaCO2, while there is no reduction in patients subjected to pH-stat management. |
| Patel RL [22] |
European Journal of Cardiothoracic Surgery (1993) |
Randomized protocol on 70 adult patient undergoing α-stat or ph stat CPB |
The cerebral extraction ratio for oxygen indicated a degree of mismatch of cerebral perfusion and demand during CPB in both pH-stat and alpha-stat groups. This mismatch was more pronounced in the pH-stat group than in the alpha-stat group, indicating greater disruption in cerebral autoregulation in the former group. |
| Gruber E [23] |
Anesthesia Analgesia (1999) |
Prospective randomized study on 35 neonates and infants managed with different hematocrit values |
An inverse relation is present between hematocrit and CBFV during DHCPB |
| Rodriguez R [24] |
Annals of Thoracic Surgery (2000) |
Observational on 124 children |
Aorto-venous can impair cerebral perfusion which may be effectively followed by Doppler flow. |
Polito et al. Cardiovascular Ultrasound 2006 4:47 doi:10.1186/1476-7120-4-47 |
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