|
Testing of pulmonary vasoreactivity at initial investigation and after six months of PDE-5 inhibitor therapy with right heart catheter |
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| HR |
RR mmHg syst/diast (mean) |
PAP mmHg syst/diast (mean) |
RA mmHg |
PCWP mmHg |
CI l/min/m2 |
SV ml/m2 |
TPR dyn × sec × cm-5 |
PVR dyn × sec × cm-5 |
|
|
|
|||||||||
| baseline |
103 |
140/89 (104) |
87/37 (56) |
28 |
8 |
1,9 |
33 |
3.178 |
1.128 |
| baseline sildenafil |
96 |
106/58 (76) |
74/14 (26) |
13 |
3 |
2,2 |
41 |
1.290 |
760 |
| six months sildenafil |
96 |
105/71 (88) |
64/27 (43) |
8 |
4 |
2,6 |
46 |
1.453 |
708 |
| six months vardenafil |
102 |
114/69 (83) |
63/25 (40) |
6 |
6 |
2,6 |
44 |
1.403 |
604 |
|
baseline = initial investigation; baseline sildenafil = 90 minutes after first dose of 25 mg sildenafil p.o.; six months sildenafil = after 6 months of therapy with sildenafil; six months vardenafil = 120 minutes after first dose of 10 mg vardenafil p.o. HR = heart rate; RR = blood pressure; PAP = pulmonary arterial pressure; RA = right atrial pressure; PCWP = pulmonary capillary wedge pressure; CI = cardiac index; SV = stroke volume; TPR = total peripheral resistance; PVR = pulmonary vascular resistance. | |||||||||
Jochmann et al. Cardiovascular Ultrasound 2005 3:26 doi:10.1186/1476-7120-3-26 |
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