Case report

Reduced coronary flow reserve in Anderson-Fabry disease measured by transthoracic Doppler echocardiography

Paweł Petkow Dimitrow¹ , Marek Krzanowski² and Anetta Undas²

¹2nd Department of Cardiology, Collegium Medicum Jagiellonian University, Cracow, Poland

²2nd Department of Internal Medicine, Collegium Medicum Jagiellonian University, Cracow, Poland

author email corresponding author email

Cardiovascular Ultrasound 2005, 3:11doi:10.1186/1476-7120-3-11

Published:	27 April 2005

Abstract

Coronary flow reserve was assessed in a patient with Anderson-Fabry disease complicated by symmetric left ventricular hypertrophy. Coronary flow reserve was measurable in all three major coronary arteries providing an opportunity to compare regional coronary flow reserve from different vascular beds. In this patient all the three vascular beds supplied diffusely hypertrophied myocardium. Coronary flow disturbances in small intramyocardial perforating arteries were visible. The coronary flow reserve was reduced to a similar level (around to 2.0) in all three major arteries. In our patient with Anderson-Fabry disease, the coronary vasodilatation was blunted in a diffuse pattern corresponding to the myocardial hypertrophy distribution. In small intramyocardial arteries coronary flow was also disturbed. Accordingly, retrograde systolic flow and accelerated anterograde diastolic flow were documented.